Laboratory for Genome Research

Focus on intellectual disability and congenital anomalies using advanced sequencing technologies.

• Whole genome sequencing by Illumina short read sequencing (NovaseqX)
• Implementation of latest analysis tools
• Transcriptome data integration
• Whole genome direct sequencing with Revio (PacBio) and/or Promethion (ONT)
• Structural variant detection
• Triplet Repeat Expansions
• Dark Regions of the Genome
• Epigenomics
• Optical Genome Mapping (Bionano)
• Functional Elucidation of Variants of Unknown Significance

Collaboration with Woman's Clinic for comprehensive prenatal genetic analysis.

• NIPT analysis and development
• EXPECT+ program for the early detection of Pregnancy Complications

Investigation of genomic aberrations and safety studies in embryo research.

• Detection of genomic and genetic aberrations in human embryos
• Influence of embryonic (mosaic) aneuploidy on implementation and development
• Safety of nuclear transfer for mitochondrial disorders or infertility
• CRISPR/Cas9 correction studies
• in collaboration with G-FaST of prof. Björn Heindryckx

Early detection and therapeutic advancement studies in cancer research.

• Early noninvasive detection of cancer by Liquid Biopsies (LQB)
• Patient stratification through noninvasive sampling
• Development of novel therapeutic approaches by neo-epitope prediction
• In close collaboration with prof. Jo Van Dorpe, prof. Karim Vermaelen, and prof. Bart Vandekerckhove